A hot pair of supplements, creatine and methylene blue dye, may not work together

image via New Scientist

April 14, 2026, 10:00 AM

• •Creatine is backed by scientific evidence for building muscle and may aid in recovery and injury prevention.
• •Methylene blue lacks sufficient clinical trials to support claims of cognitive benefits and poses potential risks.
• •Creatine monohydrate is the only proven effective form of creatine.
• •The article highlights the importance of critically evaluating supplement claims and differentiating between fact and fiction.

Creatine, a naturally occurring compound, has been proven to build muscle and offer potential benefits for athletes and aging adults, supported by extensive research. In contrast, methylene blue, a synthetic dye, lacks sufficient scientific evidence to support claims of cognitive enhancement or anti-aging effects, despite its popularity on social media. Experts caution against the use of methylene blue due to the absence of compelling human clinical trials and potential side effects, particularly for those on certain medications. The article emphasizes the importance of distinguishing between evidence-based supplements like creatine and unsubstantiated claims surrounding substances like methylene blue.

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