Just one dose of psilocybin seems to be enough to rewire the brain

image via New Scientist

August 29, 2025, 3:00 PM

• •Psilocybin, found in magic mushrooms, may remodel brain networks.
• •The drug strengthens connections between brain areas related to memory and behavior.
• •Psilocybin could weaken loops in the cortex associated with negative thoughts.
• •The research suggests possibilities for targeted brain connection remodeling.

Psilocybin, a compound found in magic mushrooms, shows promise in treating mental health conditions by remodeling brain connections. Research indicates the drug strengthens links between the retrosplenial cortex and prefrontal areas, while potentially weakening connections linked to repetitive negative thoughts. This process, observed in mice, could allow for tailored treatments that target specific brain circuits. Further studies may explore how environmental factors influence these brain changes and the overall effects of psilocybin.

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