PA-915 molecule shows long-lasting antidepressant effects without common side effects in mice

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September 29, 2025, 4:40 PM

• •PA-915, a new molecule, suppresses anxiety and depression-like behaviors in stressed mice.
• •The molecule blocks PAC1 receptors, which are linked to stress.
• •PA-915 showed long-lasting antidepressant effects similar to ketamine.
• •The molecule did not induce behavioral abnormalities in non-stressed mice.
• •Researchers suggest that blocking PAC1 receptors is a promising pathway for treating depression and anxiety.

Researchers have developed a new molecule, PA-915, that has shown promising results in treating depression and anxiety in mice. The molecule works by blocking PAC1 receptors, which are involved in stress responses. In studies, PA-915 reduced anxiety-like and depression-like behaviors in chronically stressed mice and showed long-lasting antidepressant effects. The findings suggest that PA-915 could be a potential new treatment option for stress-related disorders in humans, and further research is planned.

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