The overlooked role of sperm DNA damage in recurrent miscarriage

image via New Scientist

August 26, 2026, 10:00 AM

• •The podcast episode discusses evidence linking sperm DNA fragmentation to recurrent miscarriage and lower IVF live birth rates.
• •Standard male fertility tests usually measure sperm count, motility and morphology, but not DNA fragmentation.
• •Updated American Society for Reproductive Medicine guidance now recommends sperm DNA fragmentation testing in some recurrent pregnancy loss cases after other causes are ruled out.
• •The article says some interventions may reduce sperm DNA damage, including cutting back on alcohol, improving diet and exercise, and taking supplements.
• •The speakers argue that men are often underincluded in fertility and miscarriage discussions despite contributing to about half of infertility problems.

This Scientific American podcast transcript examines how sperm DNA fragmentation can contribute to recurrent miscarriage and poorer IVF outcomes. It says standard semen analysis often misses this problem because routine tests focus on count, motility and morphology rather than genetic damage. The episode highlights updated guidance from the American Society for Reproductive Medicine that recommends DNA fragmentation testing in select recurrent pregnancy loss cases after other causes are excluded. It also argues that earlier testing and lifestyle changes for male partners could improve care while reducing stigma and emotional isolation around infertility.

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