New Class of Drugs Blocks Wakefulness Chemical and Offers Relief from Insomnia

image via New Scientist

May 21, 2025, 1:00 PM

• •Emerging treatments include DORA drugs, which target wakefulness, cannabinoids like CBN, and wearable devices that modulate brain activity.
• •Cognitive behavioral therapy for insomnia (CBT-I) is often recommended but can have limited availability and may not work for everyone.
• •DORA drugs show promise with fewer side effects than older medications but can be expensive.
• •Research is ongoing into cannabinoids for sleep, with CBN showing potential, while CBD and THC have shown limited efficacy.
• •Digital CBT-I platforms and wearable devices are also being developed to help with sleep.

Chronic insomnia affects millions, prompting the search for new treatments beyond traditional methods. Recent advancements include DORA drugs, which target wakefulness pathways, showing fewer side effects than older medications. Research into cannabinoids like CBN shows promise, while digital platforms and wearable devices are also emerging as potential solutions. These developments offer hope for improved sleep and quality of life for those struggling with insomnia.

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