Reverse genetics system enhances vaccine development for African swine fever virus

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March 26, 2025, 8:19 PM

• •Researchers developed a reverse genetics system for African swine fever virus (ASFV) to aid in vaccine development and studying the virus's biology.
• •The system involves constructing synthetic DNA, modifying it, and introducing it into host cells to produce recombinant viruses.
• •This technology has the potential to reduce economic losses in the swine industry and can be applied to other viruses.
• •The platform offers hope for developing new vaccines and reducing the environmental footprint of the livestock sector.

Researchers from multiple institutions have developed a synthetic genomics-based reverse genetics system for the African swine fever virus (ASFV). This system allows scientists to quickly generate genetically modified versions of the virus, aiding in the development of vaccines and the study of its pathogenesis. The technology involves creating synthetic DNA, modifying it, and introducing it into host cells to produce live recombinant viruses. The system has the potential to reduce economic losses caused by ASFV and can be applied to other viruses.

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