Scientists discover hidden brain switch that tells you to stop eating

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April 6, 2026, 11:28 PM

• •Astrocytes, not just neurons, are key to appetite regulation.
• •Lactate released by tanycytes activates astrocytes.
• •Activated astrocytes release glutamate, signaling fullness.
• •This pathway may offer new treatment targets for obesity and eating disorders.

Scientists have found that astrocytes, previously considered support cells, play a key role in regulating appetite. The study reveals a signaling pathway in the hypothalamus where tanycytes release lactate after glucose intake, which then activates astrocytes. Astrocytes, in turn, release glutamate to signal neurons and suppress appetite. This discovery could pave the way for new treatments for obesity and eating disorders by targeting this astrocyte-mediated pathway.

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