Weight loss drug Ozempic cuts depression, anxiety, and addiction risk

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March 22, 2026, 12:03 PM

• •GLP-1 medications are linked to fewer psychiatric hospital visits and reduced sickness absence.
• •Semaglutide users showed a 44% lower risk of depression and a 38% reduction in anxiety disorders.
• •Substance use disorders decreased by 47% during semaglutide treatment.
• •The study highlights the need for further research to explore the underlying mechanisms.

A new study indicates that GLP-1 medications, like semaglutide, used for diabetes and obesity, may be associated with improved mental health outcomes. Researchers found that individuals using these drugs experienced fewer psychiatric hospital visits and less time off work due to mental health issues. The study analyzed data from nearly 100,000 individuals, revealing a significant reduction in depression, anxiety, and substance use disorders among those taking GLP-1 medications. While the exact mechanisms are unclear, the findings suggest potential neurobiological effects and warrant further research to fully understand the link between these medications and mental well-being.

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