The FDA approves human trials for pig kidney transplants

image via Engadget

September 9, 2025, 4:54 PM

• •eGenesis will conduct three-phase trials using CRISPR-modified pig kidneys.
• •Patients must be 50 or older, dialysis-dependent, and on the kidney transplant waitlist.
• •Successful transplants have already been performed, with some recipients now dialysis-free.
• •The trials aim to assess the long-term durability of the organs.

The FDA has approved eGenesis to begin human trials of pig-to-human kidney transplants, marking a significant advancement in xenotransplantation. These trials will involve patients with end-stage kidney disease who are on dialysis and the transplant waitlist, potentially offering a new solution to the shortage of human organs. The approval follows successful xenotransplants, including one for a 54-year-old man who no longer requires dialysis after receiving a pig kidney. These trials aim to assess the long-term durability of the organs in healthier patients.

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